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One old-fashioned approach to validate a target in the pharmaceutical industry is by correlating target inhibitions with antiparasitic activities among large numbers of drug derivatives.

The results are often indicative but hardly ever conclusive.

The Action aims at uniting scientists with different backgrounds to create synergistic interactions paving the way for antiparasitic drug discovery for diseases caused by protozoa and helminths.

The scientific aim is to bundle together the identification and validation of parasite drug targets based on the established genomes, medicinal chemistry including structure-based drug design, crystallography, bioinformatics, and drug targeting using chemical and nanotechnological approaches to improve drug performance.

Assessment and prioritisation of the most promising targets for entry into screening programmes is crucial for maximising chances of success.

Most of the current drugs used to treat these diseases are decades old and have many limitations, including the emergence of drug resistance.

This review will summarize efforts to reinvigorate the drug development pipeline for these diseases, which is driven in large part by support from major philanthropies.

The drugs used to treat these diseases are far from ideal, and many of them were introduced decades ago.

Problems associated with some of the commonly used drugs are noted in the Table 1.




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